Oesteoprotegerin, vascular calcification and atherosclerosis

Golledge, Jonathan, and Van Campenhout, Ann (2009) Oesteoprotegerin, vascular calcification and atherosclerosis. Atherosclerosis, 204 (2). pp. 321-329.

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Abstract

The association of bone pathologies with atherosclerosis has stimulated the search for common mediators linking the skeletal and the vascular system. Since its initial discovery as a key regulator in bone metabolism, osteoprotegerin (OPG) has become the subject of intense interest for its role in vascular disease and calcification. Studies in vitro and in animal models suggest that OPG inhibits vascular calcification. Paradoxically however, clinical studies suggest that serum OPG levels increase in association with vascular calcification, coronary artery disease, stroke and future cardiovascular events. This has led to an extensive debate on the potential of OPG as a biomarker of vascular disease. However the exact significance and mechanisms by which this bone-regulatory protein influences cardiovascular pathophysiology is still unclear. The need for a more complete picture is being addressed in increasing valuable research indicating OPG as not only a marker but also a mediator of vascular pathology modulating osteogenic, inflammatory and apoptotic responses. By integrating the results of recent experimental research, animal models and clinical studies, this review summarises the present understanding of the role of OPG in vascular disease and calcification.

Item ID: 5237
Item Type: Article (Refereed Research - C1)
Keywords: osteoprotegerin; vascular disease; calcification; apoptosis; inflammation
ISSN: 1879-1484
Funders: National Institute of Health, National Health and Medical Research Council Australia, James Cook University
Date Deposited: 20 Sep 2009 23:46
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Citation Count from Web of Science Web of Science 64
Downloads: Total: 6
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