Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
Kannan, M. Bobby, Moore, Corey, Saptarshi, Shruti, Somasundaram, Sahadev, Rahuma, Mohamed, and Lopata, Andreas L. (2017) Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications. Scientific Reports, 7. 15605.
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Abstract
In this study, the biocompatibility and in vitro degradation behaviour of a commercial zinc-based alloy (Zn-5 Al-4 Mg) were evaluated and compared with that of pure zinc for temporary orthopaedic implant applications. Biocompatibility tests were conducted using human alveolar lung epithelial cells (A549), which showed that the zinc alloy exhibits similar biocompatibility as compared to pure zinc. In vitro degradation evaluation was performed using weight loss and electrochemical methods in simulated body fluid (SBF) at 37 degrees C. Weight loss measurements revealed that the degradation of the zinc alloy was slightly lower during the initial immersion period (1-3 days), but marginally increased after 5 and 7 days immersion as compared to pure zinc. Potentiodynamic polarisation experiments showed that the zinc alloy exhibits higher degradation rate than pure zinc. However, electrochemical impedance spectroscopy analysis suggests that pure zinc is susceptible to localized degradation, whereas the zinc alloy exhibited passivation behaviour. Post-degradation analysis revealed localized degradation in both pure zinc and the zinc alloy.
| Item ID: | 51727 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 2045-2322 |
| Additional Information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Funders: | Australian Research Council (ARC), National Health and Medical Research Council (NHMRC) |
| Date Deposited: | 06 Dec 2017 07:43 |
| FoR Codes: | 40 ENGINEERING > 4003 Biomedical engineering > 400308 Medical devices @ 100% |
| SEO Codes: | 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100% |
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