Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
Li, Yaqi, Yin, Mingbo, Wu, Qunfeng, McManus, Donald P., Blair, David, Li, Hongyan, Xu, Bin, Mo, Xiaojin, Feng, Zheng, and Hu, Wei (2017) Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations. Parasites & Vectors, 10 (87).
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Abstract
Background: The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies the molecular epidemiology of this persistent and harmful parasite, few have explored the possibility and implications of selection in S. japonicum populations.
Methods: We analyzed diversity and looked for evidence of selection at three nuclear genes (SjIpp2, SjFabp and SjT22.6) in 13 S. japonicum populations.
Results: SjT22.6 was found to exhibit high nucleotide diversity and was under positive selection in the mountainous region of mainland China. As a tegumental protein, its secondary and tertiary structure differed between S. japonicum strains from the mountainous and lakes regions. In contrast, SjIpp2 and SjFabp had relatively low levels of nucleotide diversity and did not show significant departure from neutrality.
Conclusions: As a tegument-associated antigen-encoding gene of S. japonicum, SjT22.6 has high nucleotide diversity and appears to be under positive selection in the mountainous region of mainland China.
| Item ID: | 50762 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1756-3305 |
| Keywords: | schistosoma japonicum, nuclear genes, genetic diversity, natural selection, tegument-associated antigen |
| Additional Information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Funders: | National Natural Science Foundation of China (NNSFC), Foundation of National Science and Technology (FNST) |
| Projects and Grants: | NNSFC No. 91431104, FNST Grant No. 2012ZX10004-220, FNST Grant No. 2008ZX10004-011 |
| Date Deposited: | 20 Sep 2017 11:41 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3109 Zoology > 310902 Animal cell and molecular biology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 50% |
| SEO Codes: | 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100% |
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