Binary Systems of Nifedipine And Various Cyclodextrins in The Solid State. Thermal, FTIR, XRD studies
Brown, M.E., Glass, B.D., and Worthington, M.S. (2002) Binary Systems of Nifedipine And Various Cyclodextrins in The Solid State. Thermal, FTIR, XRD studies. Journal of Thermal Analysis and Calorimetry, 68 (2). pp. 631-646.
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Nifedipine complexes with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD), randomly methylated-β-cyclodextrin (RM-β-CD) and heptakis(2,6-O-dimethyl)-β-cyclodextrin (DM-β-CD) have been prepared by both kneading and heating methods and their behaviour studied by differential scanning calorimetry (DSC), diffuse reflectance mid-infrared spectroscopy (FTIR) and X-ray diffractometry (XRD). DSC revealed the nifedipine melting endotherm with onset at approximately 171°C for the kneaded mixtures with β-CD, γ-CD and 2HP-β-CD, thus confirming the presence of nifedipine in the crystalline state, while some decrease in crystallinity was observed in the DM-β-CD kneaded mixture. With RM-β-CD, however, broadening and shifting of the nifedipine endotherm and reduction in its intensity suggested that the kneading could have produced an amorphous inclusion complex. These differing extents of interaction of nifedipine with the cyclodextrins were confirmed by FTIR and XRD studies.
|Item Type:||Article (Refereed Research - C1)|
cyclodextrins; DSC; FTIR; inclusion compounds; nifedipine; XRD
|Date Deposited:||07 Jul 2009 04:31|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences @ 50%|