Binary Systems of Nifedipine And Various Cyclodextrins in The Solid State. Thermal, FTIR, XRD studies

Brown, Michael Ewart, Glass, B.D., and Worthington, M.S. (2002) Binary Systems of Nifedipine And Various Cyclodextrins in The Solid State. Thermal, FTIR, XRD studies. Journal of Thermal Analysis and Calorimetry, 68 (2). pp. 631-646.

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Abstract

Nifedipine complexes with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD), randomly methylated-β-cyclodextrin (RM-β-CD) and heptakis(2,6-O-dimethyl)-β-cyclodextrin (DM-β-CD) have been prepared by both kneading and heating methods and their behaviour studied by differential scanning calorimetry (DSC), diffuse reflectance mid-infrared spectroscopy (FTIR) and X-ray diffractometry (XRD). DSC revealed the nifedipine melting endotherm with onset at approximately 171°C for the kneaded mixtures with β-CD, γ-CD and 2HP-β-CD, thus confirming the presence of nifedipine in the crystalline state, while some decrease in crystallinity was observed in the DM-β-CD kneaded mixture. With RM-β-CD, however, broadening and shifting of the nifedipine endotherm and reduction in its intensity suggested that the kneading could have produced an amorphous inclusion complex. These differing extents of interaction of nifedipine with the cyclodextrins were confirmed by FTIR and XRD studies.

Item ID: 4677
Item Type: Article (Refereed Research - C1)
Additional Information:

cyclodextrins; DSC; FTIR; inclusion compounds; nifedipine; XRD

ISSN: 1572-8943
Date Deposited: 07 Jul 2009 04:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences @ 50%
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