Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition

Burrows, Jacqueline M., Bell, Melissa J., Brennan, Rebekah, Miles, John J., Khanna, Rajiv, and Burrows, Scott R. (2008) Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition. Molecular Immunology, 45 (6). pp. 1818-1824.

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Abstract

A classic feature of antigen presentation for CD8⁺ T cell recognition is that MHC class I molecules generally present peptides of 8-10 amino acids in length. However, recent studies have demonstrated that peptides of >10 residues play a significant role in immune surveillance by T cells restricted by some HLA class I alleles. In the present study, we describe several examples of unusually long viral peptides of 11 or 12 residues, recognized by CTLs in the context of HLA-B35. Interestingly, all these immunogenic peptides completely encompass shorter canonical length sequences that conform to the HLA-B35 binding motif, but which fail to stimulate detectable T cell responses. The mechanism for this phenomenon appears to involve the preferential binding to HLA-B35 of the atypically long CD8⁺ T cell target peptides over the overlapping canonical length sequences. These data suggest that the peptide length specificity of some HLA class I alleles is broad, allowing peptides of >10 residues to sometimes dominate over canonical length class I ligands as targets for T cell recognition.

Item ID: 45393
Item Type: Article (Research - C1)
ISSN: 1872-9142
Keywords: human; CTL; viral; MHC class I; antigen presentation/processing
Funders: National Health and Medical Research Council of Australia (NHMRC)
Date Deposited: 07 Sep 2016 01:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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