The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

Davies, Murray S., Berners-Price, Susan J., Cox, John W., and Farrell, Nicholas (2003) The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug. Chemical Communications, 1. pp. 122-123.

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Abstract

The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.

Item ID: 4435
Item Type: Article (Refereed Research - C1)
Keywords: aquation; chemotherapy; DNA; platinum
ISSN: 1364-548X
Date Deposited: 16 Jun 2009 03:28
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
Citation Count from Web of Science Web of Science 9
Downloads: Total: 1
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