The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug
Davies, Murray S., Berners-Price, Susan J., Cox, John W., and Farrell, Nicholas (2003) The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug. Chemical Communications, 1. pp. 122-123.
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The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||aquation; chemotherapy; DNA; platinum|
|Date Deposited:||16 Jun 2009 03:28|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%|
|Citation Count from Web of Science||