Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity

Maharaj, Deepa S., Maharaj, Himant, Daya, Santy, and Glass, Beverley D. (2006) Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity. Journal of Neurochemistry, 96 (1). pp. 78-81.

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Abstract

Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important phenomenon involved in these disorders is the alteration of iron homeostasis, with an increase in iron levels. The present study investigated whether 6-hydroxymelatonin (6-OHM) can reduce Fe2+-induced lipid peroxidation and necrotic cell damage in the rat hippocampus in vivo. It was found that 6-OHM administration proved successful in reducing Fe2+-induced neurotoxicity in rat hippocampus. This study provides some evidence of the neuroprotective effects of 6-OHM.

Item ID: 4056
Item Type: Article (Refereed Research - C1)
Keywords: melatonin; neurotoxicity
ISSN: 1471-4159
Date Deposited: 28 Oct 2009 22:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860899 Human Pharmaceutical Products not elsewhere classified @ 100%
Citation Count from Web of Science Web of Science 21
Downloads: Total: 1
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