Neutrophil labeling with [(90m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide

Gallagher, Hayley, Ramsay, Stuart C., Barnes, Jodie , Maggs, Jacqueline, Cassidy, Nathan, and Ketheesan, Natkunam (2006) Neutrophil labeling with [(90m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide. Nuclear Medicine and Biology, 33 (3). pp. 433-439.

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Abstract

99mTc]-technetium stannous colloid (TcSnC)-labeled white cells are used to image inflammation. Neutrophil labeling with TcSnC is probably phagocytic, but the phagocytic receptor involved is not known. We hypothesised that complement receptor 3 (CR3) plays a key role. Phagocytic labeling could theoretically result in neutrophil activation or priming, affecting the behaviour of labeled cells. Fluorescence-activated cell sorter (FACS) analysis side scatter measurements can assess neutrophil activation and priming.

Item ID: 3915
Item Type: Article (Refereed Research - C1)
Keywords: infection; phagocytosis; CR3; CD11b; labeled white blood cells
ISSN: 0969-8051
Date Deposited: 20 Nov 2009 00:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 80%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 20%
Citation Count from Web of Science Web of Science 23
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