Neutrophil labeling with [(90m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide
Gallagher, Hayley, Ramsay, Stuart C., Barnes, Jodie , Maggs, Jacqueline, Cassidy, Nathan, and Ketheesan, Natkunam (2006) Neutrophil labeling with [(90m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide. Nuclear Medicine and Biology, 33 (3). pp. 433-439.
PDF (Published Version)
- Published Version
Restricted to Repository staff only
99mTc]-technetium stannous colloid (TcSnC)-labeled white cells are used to image inflammation. Neutrophil labeling with TcSnC is probably phagocytic, but the phagocytic receptor involved is not known. We hypothesised that complement receptor 3 (CR3) plays a key role. Phagocytic labeling could theoretically result in neutrophil activation or priming, affecting the behaviour of labeled cells. Fluorescence-activated cell sorter (FACS) analysis side scatter measurements can assess neutrophil activation and priming.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||infection; phagocytosis; CR3; CD11b; labeled white blood cells|
|Date Deposited:||20 Nov 2009 00:51|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 80%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 20%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 20%
|Citation Count from Web of Science||
Last 12 Months: 1