A role for an animal model in determining the immune mechanisms involved in the pathogenesis of rheumatic heart disease

Gorton, D., Govan, B., Olive, C., and Ketheesan, N. (2006) A role for an animal model in determining the immune mechanisms involved in the pathogenesis of rheumatic heart disease. International Congress Series, 1289. pp. 289-292.

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Abstract

Rheumatic heart disease (RHD) is an autoimmune disease mediated by group A streptococcal (GAS) infection. To study the immune mechanisms underlying RHD, a robust animal model with immunopathology similar to that seen in humans is essential. A Lewis rat model of autoimmune valvulitis has been shown to have potential in investigating the immunopathogenesis of RHD.

In our studies, rats immunized with M protein C-region peptides developed cardiac lesions reflective of those seen in RHD patients, including mononuclear cell infiltration, granuloma formation and valvulitis. Furthermore, mononuclear cells sensitized to cardiac myosin extracted from rat heart lesions were shown to be cross-reactive with streptococcal M protein. These data add further support for using the Lewis rat model for investigating the cell-mediated responses involved in RHD and for testing the safety of GAS peptide-based vaccine candidates.

Item ID: 3898
Item Type: Article (Refereed Research - C1)
Keywords: infection; immunity; rheumatic heart disease; group A streptococcus; animal model; Lewis rat; lymphocyte
ISSN: 0531-5131
Date Deposited: 19 Nov 2009 22:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 80%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 20%
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