Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone-replacement

Sarnyai, Zoltán, McKittrick, Christina R., McEwen, Bruce S., and Kreek, Mary Jeanne (1998) Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone-replacement. Synapse, 30 (3). pp. 334-337.

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Abstract

[Extract] Chronic stress or high glucocorticoid levels have been shown to affect fundamental brain functions, including emotions, cognition, and reward/reinforcement, and may be associated with psychiatric disorders (McEwen, 1998; Piazza and LeMoal, 1997). Stress and glucocorticoids (GCs) have also been suggested as major factors influencing drug addiction (Kreek, 1996; Piazza and LeMoal, 1997). For example, chronic stress increases the vulnerability to develop psychostimulant selfadministration in a glucocorticoid-responsive manner (for a review, see Piazza and LeMoal, 1997). Moreover, rats have been shown to intravenously self-administer corticosterone (CORT) (see Piazza and LeMoal, 1997), which suggests an important role of CORT in reward related brain processes.

Item ID: 35115
Item Type: Article (Research - C1)
ISSN: 1098-2396
Keywords: corticosterone; dopamine transporter; adrenalectomy; nucleus accumbens shell
Funders: A.V. Davis Fellowship, National Alliance for Research on Schizophrenia and Depression (NARSAD), National Institute of Health (NIH), USA
Projects and Grants: NARSAD Young Investigator Award, NIH MH41256, NIH DA05130, NIH DA00049
Date Deposited: 28 Aug 2014 06:59
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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