Bertucci, Anthony, Innocenti, Alessio, Scozzafava, Andrea, Tambutté, Sylvie, Zoccola, Didier, and Supuran, Claudiu T. (2011) Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. Bioorganic and Medicinal Chemistry Letters, 21 (2). pp. 710-714.

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Abstract

The catalytic activity and the inhibition of a new coral carbonic anhydrase (CA, EC 4.2.1.1), from the scleractinian coral Stylophora pistillata, STPCA-2, has been investigated. STPCA-2 has high catalytic activity for the physiological reaction being less sensitive to anion and sulfonamide inhibitors compared to STPCA, a coral enzyme previously described. The best STPCA-2 anion inhibitors were sulfamide, sulfamic acid, phenylboronic acid, and phenylarsonic acid (KIs of 5.7–67.2 μM) whereas the best sulfonamide inhibitors were acetazolamide and dichlorophenamide (KIs of 74–79 nM). Because this discriminatory effect between these two coral CAs, sulfonamides may be useful to better understand the physiological role of STPCA and STPCA-2 in corals and biomineralization processes.

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