Formulation and stability evaluation of surfactant-free water-in-(highly volatile) oil emulsions

Jin, Yan, He, Yinghe, and Davies, Nigel (2007) Formulation and stability evaluation of surfactant-free water-in-(highly volatile) oil emulsions. In: Proceedings of the 35th Australasian Chemical Enginering Conferrence 2007, pp. 366-373. From: Chemeca 2007: academia and industry - strengthening the profession., 23-26 September 2007, Melbourne, Victoria, Australia.

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Abstract

Microencapsulation is a process where active ingredients are packaged into particles to achieve desirable effects such as control on the release of the core materials, reduction of reactivity and volatility of the core materials or promotion of easier handling. Emulsification is a critical step in (the microencapsulation process as it strongly influences not only the quality of the microcapsules producedfrom the emulsions but also the encapsulation efficiency of the dispersed phase. In this study. a series of experiments have been conducted to investigate the effect of process parameters on the stability of a water-in-oil type of emulsion, which was used for the production of microcapsules encapsulating the water phase in a subsequent step by the break up of a flow-/focused laminar emulsion jet and solvent removal by evaporation. To facilitate the solvent removal, a volatile solvent, namely, dichloromelhane, mixed with ethyl acetate for density adjustment, was used as the continuous organic phase. Poly(e-caprolactone) (PCL) was used as the capsule wall forming polymer as well as the viscosity modifier in the emulsification process. Results show that, in addition to the usual factors such as the density and viscosity ratios of the two phases and the volume fraction of the water phase in the emulsion, the manner in which the PCL was added to the system also has a strong effect on the stability of the emulsion.

Item ID: 3080
Item Type: Conference Item (Refereed Research Paper - E1)
Keywords: surfactant-free emulsions; water-in-oil emulsions; emulsion stability
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ISBN: 0-85825-844-7
Date Deposited: 29 Sep 2009 04:30
FoR Codes: 09 ENGINEERING > 0904 Chemical Engineering > 090499 Chemical Engineering not elsewhere classified @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 30%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified @ 30%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860801 Human Biological Preventatives (e.g. Vaccines) @ 51%
86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860901 Veterinary Biological Preventatives (e.g. Vaccines) @ 49%
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