Hydrogen peroxide is a true first messenger
Holmquist, L., Stuchbury, G., Steele, M., and Münch, G. (2007) Hydrogen peroxide is a true first messenger. Journal of Neural Transmission, Supplementa, 72. pp. 39-41.
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Hydrogen peroxide has been shown to act as a second messenger mediating intracellular redox-sensitive signal transduction. Here we show that hydrogen peroxide is also able to transmit pro-inflammatory signals from one cell to the other and that this action can be inhibited by extracellularly added catalase. If these data can be further substantiated, hydrogen peroxide might become as important as nitric oxide as a small molecule intercellular (first) messenger.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||inflammation; lipopolysaccharide; advanced glycation endproducts; nitric oxide; hydrogen peroxide; redox-sensitive signaling|
|Date Deposited:||22 Sep 2009 04:34|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%|
|Citation Count from Web of Science||