L-Arginine transporters in cardiovascular disease: a novel theraputic target
Chin-Dusting, J.P.F, Willems, L., and Kaye, D.M. (2007) L-Arginine transporters in cardiovascular disease: a novel theraputic target. Pharmacology and Therapeutics, 116 (3). pp. 428-436.
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The amino acid L-arginine participates in a variety of key biochemical and physiological activities, including its well-recognized role as the key substrate for nitric oxide (NO) biosynthesis. The current review describes the cellular influences on arginine metabolism with particular focus on the transport of L-arginine in the endothelium. It details the processes by which intracellular and extracellular levels of L-arginine may influence nitric oxide production and further documents the imbalance that is evident in various cardiovascular disease states. In man, impairment of L-arginine transport has been observed in hypertension, heart failure, and renal disease, and it may thus be a relevant therapeutic target for rectification of nitric oxide pathogenesis in these conditions.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||endothelium; nitric oxide; cationic amino acid transporter; L-arginine; hypertension|
|Date Deposited:||01 Oct 2009 01:08|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%|
|Citation Count from Web of Science||