Current role and future perspectives of magnetic resonance spectroscopy in radiation oncology for prostate cancer

Zapotoczna, Aleksandra, Sasso, Giuseppe, Simpson, John, and Roach III, Mark (2007) Current role and future perspectives of magnetic resonance spectroscopy in radiation oncology for prostate cancer. Neoplasia, 9 (6). pp. 455-463.

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View at Publisher Website: http://dx.doi.org/10.1593/neo.07277

Abstract

Prostatic neoplasms are not uniformly distributed within the prostate volume. With recent developments in three-dimensional intensity-modulated and imageguided radiation therapy, it is possible to treat different volumes within the prostate to different thresholds of doses. This approach has the potential to adapt the dose to the biologic aggressiveness of various clusters of tumor cells within the gland. The definition of tumor burden volume in prostate cancer can be facilitated by the use of magnetic resonance spectroscopy (MRS). The increasing sensitivity and specificity of MRS to the prostate is causing new interest in its potential role in the definition of target subvolumes at higher risk of failure following radical radiotherapy. Prostate MRS might also play a role as a noninvasive predictive factor for tumor response and treatment outcome. We review the use of MRS in radiation therapy for prostate cancer by evaluating its accuracy in the classification of aggressive cancer regions and target definition; its current role in the radiotherapy planning process, with special interest in technical issues behind the successful inclusion of MRS in clinical use; and available early experiences as a prognostic tool.

Item ID: 2693
Item Type: Article (Refereed Research - C1)
Keywords: magnetic resonance spectroposcopy; prostatic neoplasms; radiotherapy; biological imaging; chemical shift imaging
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ISSN: 1476-5586
Date Deposited: 10 Aug 2009 05:54
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
Citation Count from Web of Science Web of Science 13
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