Rates of cognitive decline in Alzheimer's disease and dementia with lewy bodies

Helmes, Edward, Bowler, John V., Merskey, Harold, Munoz, David G., and Hachinski, Vladimir C.I. (2003) Rates of cognitive decline in Alzheimer's disease and dementia with lewy bodies. Dementia and Geriatric Cognitive Disorders, 15 (2). pp. 67-71.

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Abstract

Increased interest in types of dementia has developed as more cases are identified in aging populations. Here we compare the rates of cognitive decline over time in three groups with dementia from the University of Western Ontario Dementia Study: Alzheimer's disease (AD), dementia with Lewy bodies and a group with both AD and Lewy bodies. All diagnoses were verified by autopsy using standard diagnostic methods. Cognitive impairment was measured with the Extended Scale for Dementia (ESD). Members of each group with dementia were age and sex matched with individuals without dementia as controls. The 15 cases of AD, 7 cases with Lewy bodies and 8 cases with both conditions were all free of significant vascular disease. Linear regression was used to determine the rate of changes in ESD scores over time in months. All three control groups showed no change in cognitive status over time. As expected, all groups with dementia showed progressive cognitive impairment. Analysis of the slope parameter showed that all groups deteriorated at the same rate of approximately 2 ESD points per month. Quadratic models fit better than simple linear models in all groups. Results suggest that the final rate of cognitive decline in dementia may not necessarily reflect the underlying cause.

Item ID: 269
Item Type: Article (Refereed Research - C1)
Keywords: aged, alzheimer disease [complications], alzheimer disease [diagnosis], alzheimer disease [psychology], cognition disorders [etiology], cognition disorders [psychology], comparative study, disease progression, female, humans, lewy body disease [complications], lewy body disease [diagnosis], lewy body disease [psychology], linear models, male, prognosis, psychiatric status rating scales
ISSN: 1421-9824
Date Deposited: 10 Nov 2006
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170102 Developmental Psychology and Ageing @ 34%
11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 33%
17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170103 Educational Psychology @ 33%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
Citation Count from Web of Science Web of Science 17
Downloads: Total: 1
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