Molecular aspects of phytoestrogen selective binding at estrogen receptors

Turner, Joseph V., Agatonovic-Kustrin, Snezana, and Glass, Beverley D. (2007) Molecular aspects of phytoestrogen selective binding at estrogen receptors. Journal of Pharmaceutical Sciences, 96 (8). pp. 1879-1885.

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Abstract

Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. An increase in phytoestrogen research over the past few decades has demonstrated the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. Identification of the estrogen receptor (ER) and research into various ligand classes has enabled elucidation of molecular aspects important in selective ER binding. This article explores the structural characteristics and significance of functional groups as they relate to phytoestrogen selectivity for ER binding.

Item ID: 2632
Item Type: Article (Refereed Research - C1)
Keywords: hormones; drug design; drug discovery; molecular structure; functional groups
ISSN: 1520-6017
Date Deposited: 29 Jul 2009 05:34
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
Citation Count from Web of Science Web of Science 42
Downloads: Total: 4
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