Fuzzy information fusion of classification models for high-throughput image screening of cancer cells in time-lapse microscopy

Pham, Tuan D., Tran, Dat T., and Zhou, Xiaobo (2007) Fuzzy information fusion of classification models for high-throughput image screening of cancer cells in time-lapse microscopy. International Journal of Knowledge-Based and Intelligent Engineering Systems, 11 (4). pp. 237-246.

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Abstract

Bioimaging at molecular and cellular levels requires specific image analysis methods to help life scientists develop methodologies and hypotheses in biology and biomedicine. In particular, this is true when dealing with microscopic images of cells and vessels. To facilitate the automation of cell screening, we have developed methods based on vector quantization and Markov model for classification of cellular phases using time-lapse fluorescence microscopic image sequences. Because of ambiguity inherently existing in the labeling of cell-phase feature vectors, we proposed to use relaxation labeling technique to reduce uncertainty among cell-phase models having overlapping properties. To further improve the classification rate we applied a fuzzy fusion strategy for combining individual results obtained from multiple classifiers. Our proposed image-classification methods can be useful for the task of high-content cell-cycle screening which is essential for biomedical research in the study of structures and functions of cells and molecules.

Item ID: 2624
Item Type: Article (Refereed Research - C1)
Keywords: pattern classification; signal processing
Additional Information:

Pham TD, Tran DT, and Zhou X (2007) Fuzzy information fusion of classification models for high-throughput image screening of cancer cells in time-lapse microscopy. International Journal of Knowledge-Based and Intelligent Engineering Systems, 11 (4). pp. 237-246.

© IOS and the authors.

ISSN: 1875-8827
Date Deposited: 30 Jul 2009 22:15
FoR Codes: 08 INFORMATION AND COMPUTING SCIENCES > 0801 Artificial Intelligence and Image Processing > 080109 Pattern Recognition and Data Mining @ 50%
08 INFORMATION AND COMPUTING SCIENCES > 0801 Artificial Intelligence and Image Processing > 080106 Image Processing @ 50%
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