Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3 T fMRI study
Dannlowski, Udo, Ohrmann, Patricia, Bauer, Jochen, Kugel, Harald, Arolt, Volker, Heindel, Walter, Kersting, Anette, Baune, Bernhard T., and Suslow, Thomas (2007) Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3 T fMRI study. Journal of Psychiatry and Neuroscience, 32 (6). pp. 423-429.
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Objective: In a previous study, we demonstrated that amygdala reactivity to masked negative facial emotions predicts negative judgmental bias in healthy subjects. In the present study, we extended the paradigm to a sample of 35 inpatients suffering from depression to investigate the effect of amygdala reactivity on automatic negative judgmental bias and clinical characteristics in depression.
Methods: Amygdala activity was recorded in response to masked displays of angry, sad and happy facial expressions by means of functional magnetic resonance imaging at 3 T. In a subsequent experiment, the patients performed an affective priming task that characterizes automatic emotion processing by investigating the biasing effect of subliminally presented emotional faces on evaluative ratings to subsequently presented neutral stimuli.
Results: Significant associations between (right) amygdala reactivity and automatic negative judgmental bias were replicated in our patient sample (r = –0.59, p < 0.001). Further, negatively biased evaluative processing was associated with severity and longer course of illness (r = –0.57, p = 0.001).
Conclusion: Amygdala hyperactivity is a neural substrate of negatively biased automatic emotion processing that could be a determinant for a more severe disease course.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||depressive disorder; major; magnetic resonance imaging; functional analysis; amygdala; emotion|
|Date Deposited:||20 Jul 2009 23:21|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%|
|SEO Codes:||92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%|
|Citation Count from Web of Science||