Continuous microflow photochemistry and its application in pharmaceutical drug discovery, development and production
Oelgemoeller, Michael, and Murata, Akiko (2012) Continuous microflow photochemistry and its application in pharmaceutical drug discovery, development and production. MedChem News, 22 (4). pp. 30-40.
- Published Version
Microflow photochemistry has recently emerged as a new methodology that successfully combines flow operation, micro-space and activation by light ('lab & light on a chip'). Numerous micro-photoreactors for micro-scale synthesis to technical-scale production have been already developed. The main advantages of microflow photoreactors are their beneficial light transmissions, controlled exposure times, accurate temperature control and removal of photoproducts from the irradiated area. These operation features commonly result in higher yields, enhanced selectivity, improved energy efficiencies and reductions of solvent volumes and subsequently waste. This review highlights selected examples of microflow photochemical reactors and transformations of pharmaceutical interest. It unambiguously shows the potential of this enabling technology over conventional (batch)processes.
|Item Type:||Article (Non-Refereed Research)|
|Date Deposited:||07 Nov 2012 02:38|
|FoR Codes:||03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis @ 50%
03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030504 Organic Green Chemistry @ 20%
03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030505 Physical Organic Chemistry @ 30%
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