Disseminated infection due to Nocardia trasvalensis coincident with Cryptococcus neoformans variety gattiimeningitis

Dyer, J.R., Ketheesan, N., Norton, R.E., Ashhurst-Smith, C.I.J., Keary, P., and La Brooy, J.T. (1999) Disseminated infection due to Nocardia trasvalensis coincident with Cryptococcus neoformans variety gattiimeningitis. European Journal of Clinical Microbiology and Infectious Diseases, 18 (8). pp. 587-590.

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Abstract

A case of meningitis due to Cryptococcus neoformans var. gattii coincident with disseminated Nocardia transvalensis infection is reported. Nocardia infection initially progressed despite high-dose antimicrobial therapy. Although a specific immunologic defect could not be defined, in vitro lymphocyte proliferation in response to stimulation with the Nocardia isolate was reduced. It is proposed that coinfection with Cryptococcus neoformans may have contributed to the observed impairment of lymphocyte function, leading to disseminated Nocardia disease and a suboptimal treatment response.

Item ID: 23397
Item Type: Article (Refereed Research - C1)
ISSN: 1435-4373
Date Deposited: 18 Oct 2012 05:07
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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