Molecular beam spectroscopy of molecules with low volatility via laser desorption from thin films containing particulate silver

Karaiste, R. Timo T., Atkinson, Ian M., Shorter, Jeffrey A., Knight, Alan E.W., and Keene, F. Richard (1993) Molecular beam spectroscopy of molecules with low volatility via laser desorption from thin films containing particulate silver. Analytical Chemistry, 65 (20). pp. 2776-2783.

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Abstract

A new polymer matrix containing particulate silver has been developed for the introduction of analytes with low or negligible volatility into molecular beams via laser desorption. These silver-containing film matrices (SCFM) permit stable desorption to proceed for extended periods (ca. approximately 10 h) and have been applied successfully to the nondestructive volatilization of a number of amino acids and a transition-metal compound. Analytes can be extracted directly from solution onto the SCFM surface by simply dipping the film into the solution and then air-drying the film. The laser desorption apparatus, when coupled to a supersonic molecular beam/laser ionization time-of-flight mass spectrometer, permits the detection of the analytes at femtogram levels. Furthermore, we have developed a reel-to-reel tape transport device that allows extended usage of the analyte-loaded SFCM, thereby permitting the measurement of wavelength-scanned mass-selected resonance-enhanced multiphoton ionization spectra of analytes with low or negligible volatility. We demonstrate this application with the aromatic amino acids L-tryptophan and L-phenylalanine. The degree of cooling achieved in the molecular expansion is shown to be comparable with that achieved using conventional beam sources, and the desorption yield is sufficiently stable for high-quality spectra to be measured.

Item ID: 22776
Item Type: Article (Refereed Research - C1)
Keywords: ionization mass-spectrometry; jet-cooling spectroscopy; amino-acid; tryptophan; gas-phase; supersonic jet; electronic spectroscopy; fluorescence spectroscopy; complexes; peptides; tyrosine
ISSN: 1520-6882
Date Deposited: 16 Aug 2012 02:48
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030207 Transition Metal Chemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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