Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics

Eyre, Harris, and Baune, Bernhard T. (2012) Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics. Journal of Neural Transmission, 119 (10). pp. 1147-1166.

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Abstract

The rising burden of unipolar depression along with its often related sleep disturbances, as well as increasing rates of sleep restriction in modern society, make the search for an extended understanding of the aetiology and pathophysiology of depression necessary. Accumulating evidence suggests an important role for the immune system in mediating disrupted neurobiological and chronobiological processes in depression. This review aims to provide an overview of the neuroimmunomodulatory processes involved with depression and antidepressant treatments with a special focus on chronobiology, chronotherapeutics and the emerging field of immune-circadian bi-directional crosstalk. Increasing evidence suggests that chronobiological disruption can mediate immune changes in depression, and likewise, immune processes can mediate chronobiological disruption. This may suggest a bi-directional relationship in immune-circadian crosstalk. Furthermore, given the immunomodulatory effects of antidepressants and chronotherapeutics, as well as their associated beneficial effects on circadian disturbance, we—and others—suggest that these therapeutic agents may exert their chronobiotic effects partially via the neuroimmune system. Further research is required to better elucidate the mechanisms of immune involvement in the chronobiology of depression.

Item ID: 22367
Item Type: Article (Refereed Research - C1)
Keywords: depression, antidepressant, immune, chronobiology, circadian rhythm, sleep–wake cycle
ISSN: 1435-1463
Date Deposited: 15 Nov 2012 01:12
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
Citation Count from Web of Science Web of Science 2
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