Further evidence to support a role for urocortin 2 in heart failure

Moxon, Joseph V., Emeto, Theophilus I., and Golledge, Jonathan (2012) Further evidence to support a role for urocortin 2 in heart failure. Anatolian Journal of Cardiology, 12 (2). pp. 121-122.

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Abstract

[Extract] The urocortin (UCN) group comprises 3 structurally-related peptides which are included within the corticotropin-releasing factor family (1-3). Specific receptors for UCN2 and 3 are expressed throughout the vasculature and myocardium (4), suggesting a role for these peptides in maintaining cardiovascular homeostasis. More recently, the UCNs are receiving increasing clinical interest due to a growing body of data from human, animal and in vitro studies, which highlight the therapeutic potential of these peptides. In particular, reports of improved cardiac output in heart failure patients treated with UCN2 and observed correlations of circulating UCN1 with cardiovascular disease severity confirm that the urocortins may be novel therapeutic, diagnostic and prognostic targets.

Item ID: 22067
Item Type: Article (Commentary)
Additional Information:

Turkish title for journal is "Anadolu Kardiyoloji Dergisi"

ISSN: 1308-0032
Date Deposited: 24 Jul 2012 04:12
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Citation Count from Web of Science Web of Science 2
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