Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

Holliday, Elizabeth G., Maguire, Jane M., Evans, Tiffany-Jane, Koblar, Simon A., Jannes, Jim, Sturm, Jonathan W., Hankey, Graeme J., Baker, Ross, Golledge, Jonathan, Parsons, Mark W., Malik, Rainer, McEvoy, Mark, Biros, Erik, Lewis, Martin D., Lincz, Lisa F., Peel, Roseanne, Oldmeadow, Christopher, Smith, Wayne, Moscato, Pablo, Barlera, Simona, Bevan, Steve, Bis, Joshua C., Boerwinkle, Eric, Boncoraglio, Giorgio B., Brott, Thomas G., Brown, Robert D., Cheng, Yu-Ching, Cole, John W., Cotlarciuc, Ioanna, Devan, William J., Fornage, Myriam, Furie, Karen L., Grétarsdóttir, Sólveig, Gschwendtner, Andreas, Ikram, M. Arfan, Longstreth, W.T., Meschia, James F., Mitchell, Braxton D., Mosley, Thomas H., Nalls, Michael A., Parati, Eugenio A., Psaty, Bruce M., Sharma, Pankaj, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Traylor, Matthew, Verhaaren, Benjamin F.J., Wiggins, Kerri L., Worrall, Bradford B., Sudlow, Cathie, Rothwell, Peter M., Farrall, Martin, Dichgans, Martin, Rosand, Jonathan, Markus, Hugh S., Scott, Rodney J., Levi, Christopher, and Attia, John (2012) Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nature Genetics, 44 (10). pp. 1147-1151.

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Abstract

Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR) = 1.62, P = 3.9 × 10(-8)) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR = 1.15, P = 3.9 × 10(-4); discovery and replication combined OR = 1.21, P = 4.7 × 10(-8)). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.

Item ID: 22065
Item Type: Article (Refereed Research - C1)
ISSN: 1546-1718
Date Deposited: 17 Oct 2012 07:00
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Citation Count from Web of Science Web of Science 2
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