A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients
Proby, C.M., Harwood, C.A., Neale, R.E., Green, A.C., Euvrard, S., Naldi, L., Tessari, G., Feltkamp, M.C.W., de Koning, M.N.C., Quint, W.G.V., Waterboer, T., Pawlita, M., Weissenborn, S., Wieland, U., Pfister, H., Stockfleth, E., Nindl, I., Abeni, D., ter Schegget, J., Bouwes Bavinck, J.N., Olsen, C., O'Rourke, P., Harrison, S., Buttner, Petra, Butnaru, A.C, Claudy, A., Kanitakis, J., Breuer, J., Mitchell, L, Purdie, K., Lambert, S.R., Ran, H., Pizzagalli, A., Sassi, F., Struijk, L., Wanningen, P., van der Meijden, P.Z., Plasmeijer, Elsemieke, Wolterbeek, R., Kleter, B., and van Doorn, L.J. (2011) A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients. American Journal of Transplantation, 11 (7). pp. 1498-1508.
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We examined the association between betapapillomavirus (betaPV) infection and cutaneous squamous cell carcinoma (SCC) in organ transplant recipients. A total of 210 organ transplant recipients with previous SCC and 394 controls without skin cancer were included. The presence of 25 betaPV types in plucked eyebrow hairs was determined using a human papillomavirus (HPV) DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types were detected using multiplex serology. We used multivariate logistic regression models to estimate associations between various measures of betaPV infection and SCC. BetaPV DNA was highly prevalent (>94%) with multiple types frequently detected in both groups. We found a significant association between SCC and the concordant detection of both antibodies and DNA for at least one betaPV type (adjusted OR 1.6; 95% CI 1.1;2.5). A borderline-significant association with SCC was found for HPV36 (adjusted OR 2.4; CI 1.0;5.4), with similar associations for HPV5, HPV9 and HPV24. These data provide further evidence of an association between betaPV infection and SCC in organ transplant recipients. Confirmation of a betaPV profile predictive of risk for SCC may pave the way for clinically relevant pretransplant HPV screening and the development of preventive and therapeutic HPV vaccination.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Betapapillomavirus; case-control study; cutaneous squamous cell; organ transplant recipient|
|Date Deposited:||24 May 2012 23:58|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 50%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 30%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 30%
|Citation Count from Web of Science||