Comosusols A-D and comosone A: cytotoxic compounds from the brown alga sporochnus comosus

Ovenden, Simon P.B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Wright, Anthony D., Motti, Cherie A., and Tapiolas, Dianne M. (2011) Comosusols A-D and comosone A: cytotoxic compounds from the brown alga sporochnus comosus. Journal of Natural Products, 74 (4). pp. 739-743.

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Abstract

Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosusols A−D (3−6) and comosone A (7). The structures of all isolated compounds were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values. The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI50 values in the 8−63 μM range.

Item ID: 21804
Item Type: Article (Refereed Research - C1)
ISSN: 1520-6025
Date Deposited: 13 May 2012 22:28
FoR Codes: 10 TECHNOLOGY > 1002 Environmental Biotechnology > 100201 Biodiscovery @ 50%
03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 25%
03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030403 Characterisation of Biological Macromolecules @ 25%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 75%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 25%
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