Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans

Ovenden, Simon P.B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Tapiolas, Dianne M., Wright, Anthony D., and Motti, Cherie A. (2011) Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans. Journal of Natural Products, 74 (1). pp. 65-68.

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Abstract

A new sesquiterpene benzoxazole, nakijinol B (3), its acetylated derivative, nakijinol B diacetate (6), and two new sesquiterpene quinones, smenospongines B (4) and C (5), were isolated from the methanol extract of the marine sponge Dactylospongia elegans. Also isolated were the known compounds dactyloquinone B and a 1:1 mixture of ilimaquinone and 5-epi-ilimaquinone. Their structures were determined on the basis of spectroscopic analyses and comparison with literature data. The isolated compounds were assessed for their cytotoxicity against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a normal mammalian cell line (CHO-K1). All compounds were found to have activities in the range 1.8−46 μM and lacked selectivity for tumor versus normal cell lines.

Item ID: 21803
Item Type: Article (Refereed Research - C1)
ISSN: 1520-6025
Date Deposited: 13 May 2012 22:30
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 25%
03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030403 Characterisation of Biological Macromolecules @ 25%
10 TECHNOLOGY > 1002 Environmental Biotechnology > 100201 Biodiscovery @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 75%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 25%
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