A new Diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp

Ovenden, Simon P.B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Tapiolas, Dianne M., Wright, Anthony D., and Motti, Cherie A. (2011) A new Diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp. Marine Drugs, 9 (11). pp. 2469-2478.

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Abstract

While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C4 (7) and C6 (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1–8 against a panel of human and mammalian cell lines are discussed.

Item ID: 21801
Item Type: Article (Refereed Research - C1)
Keywords: Stelletta; diketopiperazine (DKP); cyclo-(4-S-hydroxy-R-proline-R-isoleucine); bengamide; bengazole; anti-cancer activity
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ISSN: 1660-3397
Date Deposited: 08 May 2012 06:12
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 25%
03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030403 Characterisation of Biological Macromolecules @ 25%
10 TECHNOLOGY > 1002 Environmental Biotechnology > 100201 Biodiscovery @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 75%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 25%
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