Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors

Belbo, Thomes, Sinnamon, Grant, and Baune, Bernhard T. (2011) Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors. Neuropsychology Review, 21 (4). pp. 337-359.

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Abstract

Neuropsychological research in patients with affective disorders shows heterogeneous results with regard to the severity and profile of cognitive impairments. In this paper we hypothesize that the investigation of clinical (subtypes, comorbidity, traumatization, personality, severity, diurnal swings, course, duration, age of onset, biased processing, rumination, motivation, experience of failure, sleep, suicidal tendencies, computer attitudes), demographic (age, education, gender) and neurobiological factors (structural and functional brain changes, glucocorticoids, medication, ECT) that are related to cognitive performance has specified the understanding of severity and profile of neuropsychological impairments. We reviewed the literature pertaining to clinical, demographic and neurobiological factors following Pubmed and PsychInfo databases using different combinations of general key-terms including "Affective Disorder," "Depression," "Mania," "Neuropsychological," "Neurobiological," "Moderator," and "Review" as well as more specific demographic, clinical and neurobiological search terms. Findings from the literature show that the consideration of these factors has improved knowledge about the severity of neuropsychological impairments in patients with affective disorders whereas the neuropsychological profile is still poorly understood. Despite limited understanding, however, the existent results provide promising suggestions for the development of treatment programs.

Item ID: 21447
Item Type: Article (Refereed Research - C1)
Keywords: neurocognition, depression, mania,neuroimaging, intervention
ISSN: 1573-6660
Date Deposited: 17 Apr 2012 05:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 50%
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