Dengue fever viral exposure rates among Australian blood donors during local outbreaks
Flower, R.L.P., Fryk, J., Hyland , C., McBride, J., Ritchie, S., and Faddy, H. (2011) Dengue fever viral exposure rates among Australian blood donors during local outbreaks. Vox Sanguinis, 101 (S2). p. 96.
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Background: Dengue is not endemic in Australia; rather in North Queensland, outbreaks occur seasonally. One of the largest epidemics in the last 50 years took place in 2008/2009, affecting a significant geographical area of North Queensland, with separate outbreaks in Cairns (and surrounding regions; DENV-2,3,4 08–09) and Townsville (DENV-1,3 09). Collectively, in these outbreaks there were more than 1000 confirmed clinical cases, with the majority of cases occurring in the Cairns region. Given the absence of an approved screening test, the strategy utilised by the Australian Red Cross Blood Service (Blood Service) for managing the risk of transfusion-transmitted dengue was exclusion of at risk donors. During this epidemic, supplementary questioning for all donors was implemented to determine exposure risk, and fresh components were not manufactured from at risk donors.
Aims: This study aimed to estimate dengue fever viral exposure rates among Australian blood donors during this large epidemic.
Methods: Samples were collected from blood donors during the 2008/2009 epidemic and 3 months after the last confirmed cased. Selected samples were tested for the presence of the dengue NS1 antigen with commercially available ELISA-based assay kits from PanBio.
Results: Nineteen of 1020 donations collected in Cairns during the epidemic and selected for testing showed repeat reactivity towards the NS1 antigen, and one of 67 donations collected in Townsville during the epidemic and selected for testing showed repeat reactivity towards the NS1 antigen. Viral RNA was not detected in any of these NS1 reactive donations. Summary/conclusions: This study suggests recent dengue exposure in a self-declared asymptomatic population, and provides an understanding of the rate and dynamics of asymptomatic dengue infection in North Queensland during these recent outbreaks. Discordant results between NS1 and viral RNA detection needs further evaluation. Collectively, this study justifies the use of DENV management strategy during a DENV outbreak in north Queensland.
|Item Type:||Article (Abstract)|
Vox Sanguinis, Volume 101, Special Issue: Abstracts of the 22nd Regional Congress of the ISBT, Asia, Taipei, Taiwan, November 19-23, 2011
|Date Deposited:||20 Mar 2012 06:13|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 100%|
|Citation Count from Web of Science||
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