Application of the filariasis CELISA antifilarial IgG4 antibody assay in surveillance in lymphatic filariasis elimination programmes in the South Pacific

Joseph, Hayley, Maiava, Fuatai, Naseri, Take, Taleo, Fasihah, ‘Ake, Malakai, Capuano, Corinne, and Melrose, Wayne (2011) Application of the filariasis CELISA antifilarial IgG4 antibody assay in surveillance in lymphatic filariasis elimination programmes in the South Pacific. Journal of Tropical Medicine, 2011. pp. 1-8.

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Abstract

Elimination of lymphatic filariasis (LF) in the Pacific Island Countries and Territories (PICT) has been defined as <0.1% circulating filarial antigen (CFA) prevalence in children born after the implementation of successful mass drug administrations (MDAs). This research assessed the feasibility of CFA and antibody testing in three countries; Tonga, Vanuatu, and Samoa. Transmission is interrupted in Vanuatu and Tonga as evidenced by no CFA positive children and a low antibody prevalence and titre. Transmission is ongoing in Samoa with microfilaraemic (Mf) and CFA positive children and a high antibody prevalence and titre. Furthermore, areas of transmission were identified with Mf positive adults, but no CFA positive children. These areas had a high antibody prevalence in children. In conclusion, CFA testing in children alone was not useful for identifying areas of residual endemicity in Samoa. Thus, it would be beneficial to include antibody serology in the PICT surveillance strategy.

Item ID: 19990
Item Type: Article (Refereed Research - C1)
Additional Information:

Copyright © 2011 Hayley Joseph et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

ISSN: 1687-9694
Date Deposited: 28 Feb 2012 04:13
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110705 Humoural Immunology and Immunochemistry @ 10%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111711 Health Information Systems (incl Surveillance) @ 60%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 100%
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