A SPE-LC-MS/MS method for the detection of low concentrations of pharmaceuticals in industrial waste streams

Deegan, Ann-Marie, Cullen, Mark , Oelgemoeller, Michael, Nolan, Kieran, Tobin, John, and Morrissey, Anne (2011) A SPE-LC-MS/MS method for the detection of low concentrations of pharmaceuticals in industrial waste streams. Analytical Letters, 44. pp. 2808-2820.

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Abstract

A SPE-LC-MS/MS method was developed and validated for the determination of three active pharmaceutical ingredients in the wastewater of a chemical synthesis production facility. The SPE-LC-MS/MS method was validated in actual influent and effluent samples. Linearity, LOD, LOQ, repeatability, intermediate precision, and recovery were determined. The LC-MS/MS method was used for an on-going monitoring program for these pharmaceuticals in wastewater. The method development techniques, validation procedures, and results from real wastewater samples are presented in this paper.

Item ID: 19361
Item Type: Article (Refereed Research - C1)
Keywords: mass spectrometry; pharmaceuticals; solid phase extraction; wastewater
Additional Information:

Corresponding author: michael.oelgemoeller@jcu.edu.au

ISSN: 1532-236X
Date Deposited: 07 Dec 2011 04:56
FoR Codes: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030599 Organic Chemistry not elsewhere classified @ 50%
03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030108 Separation Science @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
Citation Count from Web of Science Web of Science 2
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