Vaccinomics for the major blood feeding helminths of humans

Loukas, Alex, Gaze, Soraya, Mulvenna, Jason, Gasser, Robin, Brindley, Paul, Doolan, Denise, Bethony, Jeffrey, Jones, Malcolm, Gobert, Geoffrey, Drigues, Patrick, McManus, Donald, and Hotez, Peter (2011) Vaccinomics for the major blood feeding helminths of humans. OMICS: a Journal of Integrative Biology, 15 (11). pp. 567-577.

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Abstract

Approximately one billion people are infected with hookworms and/or blood flukes (schistosomes) in developing countries. These two parasites are responsible for more disability adjusted life years lost than most other neglected tropical diseases (NTDs), and together, are second only to malaria. Although anthelmintic drugs are effective and widely available, they do not protect against reinfection, resistant parasites are likely to emerge, and mass drug administration programs are unsustainable. Therefore, there is a pressing need for the development of vaccines against these parasites. In recent years, there have been major advances in our understanding of hookworms and schistosomes at the molecular level through the use of "omics" technologies. The secretomes of these parasites have been characterized using transcriptomics, genomics, proteomics, and newly developed gene manipulation and silencing techniques, and the proteins of interest are now the target of novel antigen discovery approaches, notably immunomics. This research has resulted in the discovery, development, and early stage clinical trials of subunit vaccines against hookworms and schistosomes.

Item ID: 19283
Item Type: Article (Refereed Research - C1)
Additional Information:

This is a copy of an article published in OMICS © 2011 [copyright Mary Ann Liebert, Inc.]; OMICS is available online at: http://www.liebertonline.com.

ISSN: 1557-8100
Date Deposited: 12 Dec 2011 22:40
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
Citation Count from Web of Science Web of Science 2
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