Vaccines to combat the neglected tropical diseases
Bethony, Jeffrey M., Cole, Rhea N., Guo, Xiaoti, Kamhawi, Shaden, Lightowlers, Marshall W., Loukas, Alex, Petri, William, Reed, Steven, Valenzuela, Jesus G., and Hotez, Peter J. (2011) Vaccines to combat the neglected tropical diseases. Immunological Reviews, 239 (1). pp. 237-270.
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The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm, leishmaniasis, and schistosomiasis. Together, these conditions are considered the most common infections in low- and middle-income countries, where they produce a level of global disability and human suffering equivalent to better known conditions such as human immunodeficiency virus/acquired immunodeficiency syndrome and malaria. Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur almost exclusively in the world's poorest people living below the World Bank poverty line. In the absence of financial incentives for new products, the multinational pharmaceutical companies have not embarked on substantive research and development programs for the neglected tropical disease vaccines. Here, we review the current status of scientific and technical progress in the development of new neglected tropical disease vaccines, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities for development of new vaccines for NTDs. Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||neglected tropical diseases; tropical diseases; vaccines; parasitic vaccines|
|Funders:||Bill and Melinda Gates Foundation, Sabin Vaccine Institute, Wellcome Trust, Australian National Health and Medical Research Council|
|Date Deposited:||01 Dec 2011 05:43|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Citation Count from Web of Science||