Ascites in Ibadan, Nigeria – usefulness of albumin gradient in its etiologic diagnosis

Malabu, U.H., Olubuyide, I.O., Shaibu, M.E., and Olawuyi, F. (2006) Ascites in Ibadan, Nigeria – usefulness of albumin gradient in its etiologic diagnosis. Biomedical Research, 17 (2). pp. 105-109.

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Abstract

In a 2-year prospective study, ninety adult patients with ascites at the University College Hospital Ibadan were evaluated clinically in addition to a diagnostic work‑up protocol. Of these, 40 (44%) had liver cirrhosis, 21 (23%) had tuberculous peritonitis, 20 (22%) had malignant ascites, 5 (6%) had heart diseases and 4 (5%) had nephrotic syndrome. Albumin gradient was compared with the usual parameters of ascitic fluid analysis in the differential diagnosis of ascites. We showed that the ascitic fluid total protein concentration, the ascitic fluid/serum total protein, the ascitic fluid lactic dehydrogenase, and the ascitic fluid/serum lactic dehydrogenase were lower in the patients with liver cirrhosis than in the patients with tuberculous peritonitis (p<0.0001) or malignant ascites (p<0.0001). In contrast, the albumin gradient (serum albumin minus ascitic fluid albumin) in the patients with liver cirrhosis was significantly higher than in the patients with tuberculous peritonitis (p<0.0001) or malignant ascites (p<0.0001). There was no difference in these biochemical parameters between the patients with tuberculous peritonitis and malignant ascites. Overall, the efficiency of the biochemical parameters in correctly diagnosing patients with ascites caused by liver cirrhosis and those due to tuberculous peritonitis or malignancies was highest for albumin gradient <1.1 g/dL (96%), followed by ascitic fluid lactic dehydrogenase level >180 IU/L (77%), ascitic fluid total protein >3.0 g/dL (73%), ascitic fluid to serum lactic dehydrogenase ratio >0.6 (70%) and ascitic fluid to serum total protein ratio >0.5 (63%).

Item ID: 18878
Item Type: Article (Refereed Research - C1)
Keywords: ascites, albumin gradient, Africans
ISSN: 0970-938X
Date Deposited: 25 Oct 2011 00:56
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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