A bioequivalence and pharmacokinetic evaluation of two commercial diminazene aceturate formulations administered intramuscularly to cattle

Gummow, Bruce, Swan, G.E., and Du Preez, J.L. (1994) A bioequivalence and pharmacokinetic evaluation of two commercial diminazene aceturate formulations administered intramuscularly to cattle. Onderstepoort Journal of Veterinary Research, 61. pp. 317-326.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

Abstract

The bioequivalence of the diminazene formulation Veriben (Centaur) was determined in cattle (n = 10) by means of a single-dose, randomized cross-over experiment. The results of nine statistical procedures commonly used for bioequivalence evaluation are discussed. Veriben was found to be equivalent to Berenil (Hoechst) with respect to the area under the plasma concentration versus time curve, but not in terms of the maximum plasma drug concentration and the time to maximum plasma drug concentration. Pharmacokinetic parameters were calculated in which bioequivalence data (n = 10) together with data from an additional four cattle were used. A two-compartment model best described the pharmacokinetic behaviour of diminazene in cattle. Peak concentrations of diminazene (3,24 ± 0,16 flg/m~) were reached 49,8 (± 7,6) min after intramuscular injection of 3,5 mg/kg drug, with absorption proceeding rapidly (t'lha = 1,93 ± 0,95 h). Diminazene was slowly eliminated (t'lhJl = 222 h), resulting in a mean residence time of 13,27 d. The safe interval necessary between successive treatments of diminazene or before live babesia vaccines should be administered, and a recommended pre-slaughter withdrawal period are also discussed.

Item ID: 18670
Item Type: Article (Refereed Research - C1)
Related URLs:
ISSN: 0030-2465
Date Deposited: 06 Jun 2012 03:28
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070704 Veterinary Epidemiology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
Downloads: Total: 2
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page