MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity
Perrigoue, Jacqueline G., Saenz, Steven A., Siracusa, Mark C., Allenspach, Eric J., Taylor, Betsy C., Giacomin, Paul R., Nair, Meera G., Du, Yurong, Zaph, Colby, van Rooijen, Nico , Comeau, Michael R., Pearce, Edward J., Laufer, Terri M., and Artis, David (2009) MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nature Immunology, 10 (7). pp. 697-705.
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Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell–mediated priming was insufficient for the development of T helper type 2 cell–dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II–dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.
|Item Type:||Article (Refereed Research - C1)|
|Date Deposited:||24 Oct 2011 07:08|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%|