Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma

Zhao, Hong, Dong, Ying, Quan, Jingjing, Smith, Robert, Lam, Alfred, Weinstein, Stephen, Clements, Judith, Johnson, Newell W., and Gao, Jin (2011) Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma. Head and Neck, 33 (4). pp. 566-572.

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Abstract

Background

Very few articles have been written about the expression of kallikreins (KLK4 and KLK7) in oral cancers. Therefore, the purpose of this study was to examine and report on their prognostic potential.

Methods

Eighty archival blocks of primary oral cancers were sectioned and stained for KLK4 and KLK7 by immunohistochemistry. The percentage and the intensity of malignant keratinocyte staining were correlated with patient survival using Cox regression analysis.

Results

Both kallikreins were expressed strongly in the majority of tumor cells in 68 of 80 cases: these were mostly moderately or poorly differentiated neoplasms. Staining was particularly intense at the infiltrating front. Patients with intense staining had significantly shorter overall survival (p < .05).

Conclusion

This is the first observation on the patient survival influenced by kallikrein expression in oral carcinoma. The findings are consistent with those for carcinomas at other sites, in particular the prostate and ovary. KLK4 and/or KLK7 immunohistochemistry seems to have diagnostic and prognostic potential in this disease.

Item ID: 18380
Item Type: Article (Refereed Research - C1)
Keywords: oral squamous cell carcinoma, kallikrein serine proteases, immunohistochemistry, prognosis
ISSN: 1097-0347
Date Deposited: 26 Oct 2011 22:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110599 Dentistry not elsewhere classified @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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