The clinicopathological roles of alpha‐B‐crystallin and p53 expression in patients with head and neck squamous cell carcinoma
Boslooper, Karin, King-Yin Lam, Alfred, Gao, Jin, Weinstein, Stephen, and Johnson, Newell (2008) The clinicopathological roles of alpha‐B‐crystallin and p53 expression in patients with head and neck squamous cell carcinoma. Pathology, 40 (5). pp. 500-504.
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Aims: The aim of the study was to investigate the expression of alpha‐B‐crystallin and p53 in head and neck squamous cell carcinoma (HNSCC).
Methods: Alpha‐B‐crystallin and p53 expressions from 118 HNSCC were studied by immunohistochemistry and correlated with clinicopathological parameters.
Results: Alpha‐B‐crystallin expression was seen in 28% (n = 33) of HNSCC. All except one poorly differentiated HNSCC were negative for alpha‐B‐crystallin. p53 expression was seen in 63% (n = 73) of HNSCC and was more common in moderately/poorly differentiated HNSCC (p = 0.034). The proportion of cases with positive staining for either alpha‐B‐crystallin or p53 was different in different anatomical locations in the head and neck. Patients with HNSCC having a high portion of tumour cells expressing p53 had a shorter survival than the other groups (p = 0.032).
Conclusion: The expression of p53 and alpha‐B‐crystallin were related to the differentiation and site of the HNSCC. Alpha‐B‐crystallin was not a prognostic marker for HNSCC.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||head and neck, squamous cell carcinoma, heat shock protein, alpha B-crystallin, p53|
|Date Deposited:||29 Sep 2011 02:39|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%|