Infection with the carcinogenic human liver fluke, Opisthorchis viverrini
Smout, Michael J., Sripa, Banchob, Laha, Thewarach, Mulvenna, Jason, Gasser, Robin B. , Young, Neil D., Bethony, Jeffrey M., Brindley, Paul J., and Loukas, Alex (2011) Infection with the carcinogenic human liver fluke, Opisthorchis viverrini. Molecular BioSystems, 7 (5). pp. 1367-1375.
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Throughout Southeast Asia there is a strikingly high incidence of cholangiocarcinoma (CCA—hepatic cancer of the bile duct epithelium), particularly in people from rural settings in Laos and Northeast Thailand who are infected with the liver fluke, Opisthorchis viverrini, one of only three carcinogenic eukaryotic pathogens. More ubiquitous carcinogenic microbes, such as Helicobacter pylori, induce cancer in less than 1% of infected people, while as many as one-sixth of people with opisthorchiasis will develop CCA. The mechanisms by which O. viverrini causes cancer are multi-factorial, involving mechanical irritation from the activities and movements of the flukes, immunopathology, dietary nitrosamines and the secretion of parasite proteins that promote a tumourigenic environment. Genomic and proteomic studies of the liver fluke secretome have accelerated the discovery of parasite proteins with known/potential roles in pathogenesis and tumourigenesis, establishing a framework towards understanding, and ultimately preventing, the morbidity and mortality attributed to this highly carcinogenic parasite.
|Item Type:||Article (Refereed Research - C1)|
|Date Deposited:||22 Aug 2011 00:23|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Citation Count from Web of Science||