Activity and toxicity of Cr(III)-enriched Grifola frondosa in insulin-resistant mice

Xu, Qiang, and Guo, Jianyou (2009) Activity and toxicity of Cr(III)-enriched Grifola frondosa in insulin-resistant mice. Biological Trace Element Research, 131 (3). pp. 271-277.

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Abstract

This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions.

Item ID: 17695
Item Type: Article (Refereed Research - C1)
Keywords: chromium, Grifola frondosa, glucose tolerance, insulin, organ masses
ISSN: 1559-0720
Date Deposited: 03 Nov 2011 00:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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