ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis

Jennings, Ernest A., Christie, MacDonald J., and Sessle, Barry J. (2006) ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis. NeuroReport, 17 (14). pp. 1507-1510.

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Abstract

Ionotropic purine receptors (P2X) have been implicated in nociceptive neurotransmission. In this study, we examine the actions of the P2X receptor agonist α,β methylene adenosine 5'-triphosphate on excitatory neurotransmission in neurons in the deep and superficial laminae of the trigeminal spinal subnucleus caudalis (Vc), which receives nociceptive inputs from the craniofacial region. Alpha, beta methylene adenosine 5'-triphosphate caused an increase in spontaneous excitatory neurotransmission (miniature excitatory postsynaptic currents) in neurons in deep but not superficial laminae of Vc; this effect could be inhibited by the P2X receptor antagonist 2,3-O-2,4,6-trinitrophenyl-ATP. Conversely, the TRPV1 agonist capsaicin caused an increase in miniature excitatory postsynaptic currents in neurons in the superficial but not deep laminae. These data suggest that α,β methylene adenosine 5'-triphosphate acts on presynaptic terminals to increase glutamatergic neurotransmission in deep Vc neurons.

Item ID: 17688
Item Type: Article (Refereed Research - C1)
Keywords: oro-facial pain, purinoceptor P2X3, P2X2, trigeminal caudal nucleus
ISSN: 1473-558X
Date Deposited: 27 Sep 2011 06:27
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060105 Cell Neurochemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
Citation Count from Web of Science Web of Science 2
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