Presumed guilty: natural killer T cell defects and human disease

Berzins, Stuart P., Smyth, Mark J., and Baxter, Alan G. (2011) Presumed guilty: natural killer T cell defects and human disease. Nature Reviews Immunology, 11 (2). pp. 131-142.

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Abstract

Natural killer T (NKT) cells are important regulatory lymphocytes that have been shown in mouse studies, to have a crucial role in promoting immunity to tumours, bacteria and viruses, and in suppressing cell-mediated autoimmunity. Many clinical studies have indicated that NKT cell deficiencies and functional defects might also contribute to similar human diseases, although there is no real consensus about the nature of the NKT cell defects or whether NKT cells could be important for the diagnosis and/or treatment of these conditions. In this Review, we describe the approaches that have been used to analyse the NKT cell populations of various patient groups, suggest new strategies to determine how (or indeed, if) NKT cell defects contribute to human disease, and discuss the prospects for using NKT cells for therapeutic benefit.

Item ID: 17245
Item Type: Article (Refereed Research - C1)
ISSN: 1474-1741
Date Deposited: 21 Jun 2011 06:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
Citation Count from Web of Science Web of Science 2
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