Progress on the transcriptomics of carcinogenic liver flukes of humans - unique biological and biotechnological prospects

Young, Neil D., Jex, Aaron R., Cantacessi, Cinzia, Campbell, Bronwyn E., Laha, Thewarach, Sohn, Woon-Mok, Sripa, Banchob , Loukas, Alex, Brindley, Paul J., and Gasser, Robin B. (2010) Progress on the transcriptomics of carcinogenic liver flukes of humans - unique biological and biotechnological prospects. Biotechnology Advances, 28 (6). pp. 859-870.

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Liver flukes, such as Clonorchis sinensis and Opisthorchis viverrini, are food-borne parasites that have a major impact on the health of humans and animals, particularly in Asia. However, the impact of C. sinensis and O. viverrini, in particular, is exacerbated in that these parasites can induce a malignant, untreatable cancer (cholangiocarcinoma, CCA) in chronically infected people. As a result, these flukes are classified as Group 1 carcinogens. Despite their substantial socio-economic importance, little is known about these parasites and their relationship with the definitive hosts at the molecular level. Here, we provide a background on these two carcinogenic flukes and review recent progress on characterizing their transcriptomes using next-generation technologies. We also describe the prospects that the transcriptomes of C. sinensis and O. viverrini provide as a resource for future -omic explorations and efforts to develop improved methods of intervention and control against these important pathogens and CCA, leading to biotechnological outcomes.

Item ID: 17087
Item Type: Article (Refereed Research - C1)
Keywords: liver flukes (Opisthorchiidae); Clonorchis sinensis; Opisthorchis viverrini; carcinogens; cholangiocarcinoma; transcriptomics Bioinformatics
ISSN: 1873-1899
Funders: Australian Research Council (RGB), Endeavour Fellowship (NDY)
Date Deposited: 10 May 2011 05:07
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
Citation Count from Web of Science Web of Science 2
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