The immunology of human hookworm infections
McSorley, H.J., and Loukas, A. (2010) The immunology of human hookworm infections. Parasite Immunology, 32 (8). pp. 549-559.
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Hookworms are one of the most prevalent parasites of humans in developing countries, but we know relatively little about the immune response generated to hookworm infection. This can be attributed to a lack of permissive animal models and a relatively small research community compared with those of the more high-profile parasitic diseases. However, recently, research has emerged on the development of vaccines to control hookworm infection and the use of hookworm to treat autoimmune and allergic disorders, contributing to a greater understanding of the strategies used by hookworms to modulate the host's immune response. A substantial body of research on the immunobiology of hookworms originates from Australia, so this review will summarize the current status of the field with a particular emphasis on research carried out 'down under'.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||autoimmunity, hookworm, hygiene hypothesis, immune response, immunoregulation, vaccine|
|Funders:||National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC), The Broad Foundation, Sabin Vaccine Institute , Bill and Melinda Gates Foundation|
|Date Deposited:||10 May 2011 10:00|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Citation Count from Web of Science||