Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites
Pearson, Mark S., Ranjit, Najju, and Loukas, Alex (2010) Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites. Biological Chemistry, 391 (8). pp. 901-911.
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Proteases are pivotal to parasitism, mediating biological processes crucial to worm survival including larval migration through tissue, immune evasion/modulation and nutrient acquisition by the adult parasite. In haematophagous parasites, many of these proteolytic enzymes are secreted from the intestine (nematodes) or gastrodermis (trematodes) where they act to degrade host haemoglobin and serum proteins as part of the feeding process. These proteases are exposed to components of the immune system of the host when the worms ingest blood, and therefore present targets for the development of anti-helminth vaccines. The protective effects of current vaccine antigens against nematodes that infect humans (hookworm) and livestock (barber's pole worm) are based on haemoglobin-degrading intestinal proteases and act largely as a result of the neutralisation of these proteases by antibodies that are ingested with the blood-meal. In this review, we survey the current status of helminth proteases that show promise as vaccines and describe their vital contribution to a parasitic existence.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||haemoglobin, helminth, hookworm, parasite, protease, vaccine|
|Date Deposited:||10 May 2011 06:12|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Citation Count from Web of Science||