A role for Leukemia Inhibitory Factor (LIF) during implantation in the mare

Villani, M., Vriend, B.A.M, Paris, D.B.B.P., and Stout, T.A.E (2010) A role for Leukemia Inhibitory Factor (LIF) during implantation in the mare. Animal Reproduction Science, 121S (1-2). s309-s309.

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Abstract

The majority of early pregnancy losses in the mare occur between days 15 and 45 of gestation, i.e. the period in which the conceptus must form a stable attachment with the endometrium (Allen, 2001). At present, little is known about the pathways that regulate equine implantation, orhow‘implantation failure’ contributes to pregnancy loss. Leukemia Inhibitory Factor (LIF) plays a critical role in murine blastocyst development and implantation, as demonstrated by the failure of wild-type embryos to survive in the uterus of LIF-knockout dams unless the latter receive LIF supplementation (Stewart et al., 1992). Expression of LIF and its receptors (LIF-R and gp130) in the pregnant horse has not been reported. However, the horse is an interesting species in which to study ‘implantation’ because conceptus–endometrium apposition and attachment occurs over an unusually prolonged interval. The aim of this study was to examine gene expression for LIF, LIF-R and gp130 in the early conceptus, and in the endometrium of cycling and early pregnant mares.

Item ID: 17023
Item Type: Article (Abstract)
ISSN: 1873-2232
Date Deposited: 12 May 2011 05:06
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0702 Animal Production > 070206 Animal Reproduction @ 100%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8303 Livestock Raising > 830306 Horses @ 100%
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