Current status of medical management for abdominal aortic aneurysm

Golledge, Jonathan, and Norman, Paul E. (2011) Current status of medical management for abdominal aortic aneurysm. Atherosclerosis, 217 (1). pp. 57-63.

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Abstract

Previous trials indicate that surgical management of small abdominal aortic aneurysms (AAA) does not reduce mortality. The medical management of AAA, however, has to a large degree been ignored until recently. Medical management is not only needed to limit the expansion of small AAAs but also to reduce the high incidence of other cardiovascular events in these patients. In this review current evidence regarding medical therapy for patients with small AAAs is discussed. Four current randomised controlled trials are examining the efficacy of exercise, doxycycline and angiotensin converting enzyme inhibition in limiting AAA progression. A further trial using a mast cell stabilisation agent is expected to start soon. It is anticipated that a range of novel therapies for small AAAs will be identified within the next decade.

Item ID: 16761
Item Type: Article (Refereed Research - C1)
Keywords: abdominal aortic aneurysms; medical therapy; randomised controlled trials
ISSN: 1879-1484
Date Deposited: 27 Jun 2011 06:15
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Citation Count from Web of Science Web of Science 25
Downloads: Total: 6
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