The effect of titanium particles on rat bone marrow stem cells in vitro

Meng, Bo, Chen, Junjie, Guo, Dawei, Ye, Qingsong, and Liang, Xing (2009) The effect of titanium particles on rat bone marrow stem cells in vitro. Toxicology Mechanisms and Methods, 19 (9). pp. 552-558.

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Abstract

In arthroplasty prostheses and dental implant, titanium is an excellent biocompatible material for its advanced physical qualities and better biocompatibility. However, it was reported that high ratios of titanium particles can be liberated due to the continual loading or articulation cycles of the implant. Because bone marrow stem cells (BMSCs) located adjacent to the implant are critical contributors to osseous tissue integrity, this study researched the influence of titanium particles on BMSCs' viability, proliferation, and cell skeleton. In addition, the phagocytosis of titanium particles by BMSCs and expression of tumor suppressor protein p53 were also examined. It was found that exposure of BMSCs to titanium particles disrupted their viability and proliferation in vitro, which may due to the phagocytosis of titanium particles by BMSCs. Moreover, cell skeleton was destroyed and the p53 protein level increased as the titanium particles were added. For these results, it was concluded that titanium particles had a cytotoxic effect on BMSCs in vitro and would inhibit the bone formation around the implant.

Item ID: 16252
Item Type: Article (Refereed Research - C1)
Keywords: titanium, particles, cytotoxity, bone marrow stem cells
ISSN: 1537-6524
Date Deposited: 23 Jun 2011 07:18
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110501 Dental Materials and Equipment @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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